Microsoft Corp Chairman Bill Gates reacts during a news conference in Tokyo May 7, 2008. [Agencies]

SEATTLE June 27, (Agencies)-- It is almost unthinkable that any one human could pick up where Bill Gates leaves off when he ends his full-time tenure Friday as Microsoft's leader.

But as Gates bones up on epidemiology at his charitable foundation, the software company he built with a mix of visionary manifestos and extreme hands-on management must still wake up Monday to face hard problems even he could not solve. Among them: beating Google Inc. on the Web while fending off its attacks on desktop computing.

When Microsoft Corp. announced in 2006 that Gates planned to go part-time as board chairman, so he could spend more time on his global health charity, it named two senior executives to guide the company's overall technical direction.

Gates' recent remarks, however, indicate Microsoft is looking to a much larger group of employees for big-picture guidance and long-term planning. But it's not yet clear whether the company can replicate his thinking with more traditional corporate processes _ or whether it should even be trying.

From Microsoft's start in 1975, Gates has been the company's genius programmer, its technology guru, its primary decision maker and its ruthless and competitive leader. He would famously disappear into the solitude of a country cabin to digest employee-written papers and ponder the future of the industry, then emerge with manifestos, including the 1995 "Internet Tidal Wave" memo, that could shift the focus of the entire company.

He is credited by analysts and academics for the emergence of software as a moneymaking industry; previously it had been a pastime for hobbyists or a subset of the hardware sector. He is revered by many engineers, despite his propensity to fling expletives at underlings whose ideas he scorned. And he has built Microsoft into a hugely successful monopoly that has only grown stronger despite major losses in antitrust trials in the U.S. and Europe.

At a May gathering of chief executive officers at Microsoft's Redmond, Wash., headquarters, Gates outlined how he hoped to translate the work once done within the singular confines of his brain into the sort of group projects that could be managed with the company's own collaboration software.